Topic 7 – Biogalenic and Therapeutic Innovations

Presentation

Team members of Topic 7

 

Name	Position	Phone	e-mail
Thierry VANDAMME	Full Professor (CE2)	+33 (0)3 68 85 41 06	vandamme@unistra.fr
Nicolas ANTON	Associate Professor (HDR, HC)	+33 (0)3 68 85 42 51	nanton@unistra.fr
Guillaume CONZATTI	Associate Professor	+33 (0)3 68 85 43 05	conzatti@unistra.fr
Abedalaziz ABBARA	PhD Student		abedalaziz.abbara@etu.unistra.fr
Ali Imran ABIB	PhD Student		ali.imranabid50@gmail.com
Carla FAIVRE	PhD Student		carla.faivre@etu.unistra.fr
Mohamed ELHASSAN	PhD Student		mohamed-ahmed.mohamed-elhassan-ahmed@etu.unistra.fr

Fundings

• 2024 ANR FluoLLPS Fluorescence tools to characterize Liquid-Liquid Phase Separation (PI Nicolas ANTON)
• 2023 IDEX funding « recherche exploratoire » Innovative physicochemical and fluorescent tools to characterize liquid-liquid phase separation (PI Nicolas ANTON)
• 2023 PHC Utique 2023 Development of innovative pH-sensitive liposomes and nano-emulsions for organ preservation solutions (PI Nicolas ANTON)
• 2022 ANR SenEmul “Green” bio-mimetic platform based on lipid nanoemulsions for detection of endothelial senescence (PI Nicolas ANTON / Thierry VANDAMME)
• 2021 ANR PAANIC Pulmonary Administration of Antibiotic Nano-emulsion to treat gram-negative bacteria InfeCtions (Consortium coordinator Nicolas ANTON)
• 2020 IDEX « attractivité » (PI Guillaume CONZATTI)
• 2020 ANR LABRICON Laser-assisted fabrication of silicone-based patches for transdermal drug release (PI Thierry VANDAMME)
• 2017 ANR BioCaps Programmable release of drugs by rolled up biocapsules (PI Thierry VANDAMME)

Publications of Topic 7

2023

• Carbohydrate Polymer Technologies and Applications, 2023, in press.
  Surface modification of silica nanoparticles by chitosan for stabilization of water-in-oil Pickering emulsions
  Heidari, F.; Jafari, S.M.*; Ziaiifar, A.M.; Anton, N.
• Acta Biomaterialia, 2023, in press.
  CT and X-ray Contrast Agents: Current Clinical Challenges and the Future of Contrast
  Owens, T.C.*; Anton, N.; Attia, M.F.*
• Trends in Biotechnology, 2023, in press.
  Custom-made meniscus biofabrication.
  Vignes, H.; Smaida, R.; Conzatti, G.; Hua, G.; Benkirane-Jessel, N.
• Journal of Microencapsulation, 2023, accepted.
  Impact of Formulation design and Lyophilization on the Physicochemical Characteristics of Finasteride Nanosystems.
  Irfan, M.M.; Shah, S.U.*; Shah, K.U.; Anton, N.; Idoux-Gillet, Y.; Conzatti, G.; Shah, K.U.; Perennes, E.; Vandamme, T.F.
• Expert Opinion on Drug Delivery, 2023, 20, 93-114.
  Updated insight into the characterization of nano-emulsions.
  Wang, X.; Anton, H.; Vandamme, T.; Anton, N.*
• Physical Chemistry Chemical Physics, 2023, 25, 1177-1186.
  Study of surfactants cross-linking by click chemistry on a model water/oil interface.
  Brou, G.A.; Gbassi, G.K.; Shulov, I.; Seralin, A.; Klymchenko, A.S.; Vandamme, T.F.; Anton, N.*
• ACS Applied Bio Materials, 2023, 6, 1, 246–256.
  Controlled release and capture of aldehydes by dynamic imine chemistry in nano-emulsions: from delivery to detoxification.
  Liu, F.; Anton, N.; Niko, Y.; Klymchenko, A.*

2022

• Pharmaceutics, 2022, 14(8), 1561.
  Preparation of Pickering Emulsions Stabilized by Modified Silica Nanoparticles via the Taguchi Approach.
  Heidari, F.; Jafari, S.M.*; Ziaiifar, A.M.; Anton, N.
• Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 645, 128858.
  Study of the spontaneous nano-emulsification process with different octadecyl succinic anhydride derivatives.
  Wang, S.; Collot, M.; Vandamme, T.F.; Anton, N.*

2021

• Pharmaceutics, 2021, 13(7), 1030.
  Water-in-oil nano-emulsions prepared by spontaneous emulsification: new insights on the formulation process.
  Akram, S.; Anton, N.; Omran, Z.*; Vandamme, T.F.*
• Nanomaterials, 2021, 11(3), 826.
  Ultrabright Green-Emitting Nanoemulsions Based on Natural Lipids-BODIPY Conjugates
  Wang, X.; Bou, S.; Klymchenko, A.S.; Anton, N.*; Collot, M.*
• Nano Select, 2021, 2(5), 948-957.
  Programming of drug release via rolling-up of patterned biopolymer films
  Pedron, R.; Vandamme, T.F.; Luchnikov, V.A.*
• International Journal of Pharmaceutics, 2021, 605, 120810.
  Characterization of a hyaluronic acid-based hydrogel containing an extracellular oxygen carrier (M101) for periodontitis treatment : An in vitro study
  Özçelik, H.; Batool, F.; Corre, M.; Garlaschelli, A.; Conzatti, G.; Stutz, C.; Petit, C.; Delpy, E.; Zal, F.; Leize-Zal, E.; Huck, O.*
• ACS Applied Nano Materials, 2021, 4(5), 5319-5329.
  Controlled Synthesis of NaYF4:Yb,Er Upconversion Nanocrystals as Potential Probe for Bioimaging: A Focus on Heat Treatment.
  Kavand, A; Serra, C.A.; Blanck, C.; Lenertz, M.; Anton, N.; Vandamme, T.F.; Mély, Y.; Przybilla, F.; Chan-Seng, D.*
• Nanomedicine, Nanotechnology, Biology and Medicine, 2021, 34, 102374.
  Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells
  Belcastro, E.; Rehman, A.U.; Remila, L.; Park, S.H.; Gong, D.S.; Anton, N.; Auger, C.; Lefebvre, O.; Goetz, J.G.; Collot, M.; Klymchenko, A.S.; Vandamme, T.F.; Schini-Kerth, V.B.*
• Langmuir, 2021, 37(8), 2586-2595.
  The pH-induced specific area changes of unsaturated lipids deposited onto a bubble interface
  Anton, N.*; Pierrat, P.; Brou, G.; Gbassi, G.; Omran, Z.; Lebeau, L.; Vandamme, T.F.; Bouriat, P.*
• Soft Matter, 2021, 17, 1788-1795.
  Tunable Functionalization of Nano-emulsions Using Amphiphilic Polymers
  Rehman, A.U.; Anton, N.*; Bou, S.; Schild, J.; Messaddeq, N.; Vandamme, T.F.; Akram, S.; Klymchenko, A.; Collot, M.*
• Angewandte Chemie Int. Ed., 2021, 60(12), 6573-6580.
  Drug‐sponge lipid nanocarrier for in situ cargo loading and release using dynamic covalent chemistry
  Liu, F.; Niko, Y.; Bouchaala, R.; Mercier, L.; Lefebvre, O.; Andreiuk, B.; Vandamme, T.; Goetz, J.G.; Anton, N.; Klymchenko, A.S.*
• ChemBioChem, 2021, 22(4), 657-661.
  Self-organization properties of a GPCR binding peptide incorporating fluorinated tail studied by fluorine NMR
  Jourdain de Muizon, C.; Ramanoudjame, S.M.; Esteoulle, L.; Ling, C.; Brou, G.; Anton, N.; Vandamme, T.F.; Delsuc, M.A.; Bonnet, D.*; Kieffer, B.*
• Advanced Healthcare Materials, 2021, 10(1); 2001289.
  Dye-loaded nanoemulsions: biomimetic fluorescent nanocarriers for bioimaging and nanomedicine
  Klymchenko, A.S.*; Liu, F.; Collot, M.; Anton, N.

2020

• European Polymer Journal, 2020, 137, 109935.
  Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil
  Kavand, A.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D.*
• Evidence-Based Complementary and Alternative Medicine (eCAM), 2020, vol. 2020, 6976973
  Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation
  Omran, Z.; Bader, A.; Porta, A.; Vandamme, T.; Anton, N.; Alehaideb, Z.; El-Said, H.; Faidah, H.; Essa, A.; Vassallo, A.*; Halwani, M.*
• Polymer Chemistry, 2020, 11, 4313-4325.
  Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles
  Kavand, A.; Blanck, C.; Przybilla, F.; Mély, Y.; Anton, N.; Vandamme, T.F.; Serra, C.A.; Chan-Seng D.*
• Journal of Colloid and Interface Science, 2020, 578, 768-778.
  Further insights into release mechanisms from nano-emulsions, assessed by a simple fluorescence-based method
  Wang, X.; Collot, M.; Omran, Z.; Vandamme, T.F.; Klymchenko, A.; Anton, N.*
• International Journal of Pharmaceutics, 2020, 586, 119534.
  Development of a thermosensitive statin loaded chitosan-based hydrogel promoting bone healing
  Petit, C.; Batool, F.; Stutz, C.; Anton, N.; Klymchenko, A.S.; Vandamme, T.; Benkirane-Jessel, N.; Huck, O.*
• International Journal of Pharmaceutics, 2020, 585, 119481.
  Production of lipophilic nanogels by spontaneous emulsification
  Ding, S.; Mustafa, B.; Anton, N.*; Serra, C.A.*; Chan-Seng, D.; Vandamme, T.F.*
• Journal of Materials Chemistry B, 2020, 8, 5938-5944.
  Near infrared fluorogenic probe as a prodrug model for evaluating cargo release by nanoemulsions
  Bou, S.; Wang, X.; Anton, N.; Klymchenko, A.S.; Collot, M.*
• Soft Matter, 2020, 16, 4173-4181.
  Lipid-Core/Polymer-Shell Hybrid Nanoparticles: Synthesis and Characterization by Fluorescence Labeling and Electrophoresis
  Bou, S.; Wang, X.; Anton, N.; Bouchaala, R. ; Klymchenko, A.S.; Collot, M.*
• Colloids and Surfaces B: Biointerfaces, 2020, 191, 111010.
  Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs
  Dieng, S.M.*; Omran, Z.*; Anton, N.; Thioune, O.; Djiboune, A.R.; Sy, P.M.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.*
• Journal of Controlled Release, 2020, 321, 385-311.
  Synthesis and functionalization of hyperbranched polymers for targeted drug delivery
  Kavand, A.; Anton, N.; Vandamme, T.F.; Serra, C.A.; Chan-Seng, D.*

2019

• Pharmaceutics, 2019, 11(11), 601.
  Synthesis, Principles and Properties of magnetite nanoparticles for in vivo imaging applications – A review
  Wallyn, J.; Anton, N.*; Vandamme, T.F.*
• Soft Matter, 2019, 15, 8164-8174
  Pickering nano-emulsions stabilized by solid lipid nanoparticles as temperature sensitive drug delivery system
  Dieng, S.M.; Anton, N.*; Bouriat, P.; Thioune, O.; Sy, P.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.F.*
• Journal of Pharmacy and Pharmacology, 2019, 71(8), 1185-1198.
  An overview of active and passive targeting strategies to improve the nano-carrier’s efficiency to tumor sites
  Attia, M.F.*; Anton, N.; Wallyn, J.; Omran, Z.H.*; Vandamme, T.F.*
• Pharmaceutical Research, 2019, 36(6), 78.
  Biomedical imaging: principles, technologies, clinical aspects, contrast agents, limitations and future trends in nanomedicines
  Wallyn, J.; Anton, N.*; Akram, S.; Vandamme, T.F.
• ACS Applied Materials & Interfaces, 2019, 11(14), 13079-13090.
  Optimizing the Fluorescent Properties of Nano-emulsions for Single Particle Tracking in Live Cells
  Wang, X.; Anton, N.*; Pichandi, A.; Anton, H.; Kyong, F.T.; Vandamme, T.F.; Klymchenko, A.S.*; Collot, M.*
• Langmuir, 2019, 35(6), 2313-2325.
  Towards the formulation of stable micro and nano double emulsions through silica coating of internal water droplets
  Akram, S.; Wang, X.; Vandamme, T.F.; Collot, M.; Ur Rehman, A.; Messaddeq, N.; Mély, Y.; Anton, N.*
• Journal of Controlled Release, 2019, 295, 31-49.
  Double emulsions prepared by two-step emulsification: History, State-of-the-art and Perspective
  Ding, S.; Serra, C.A.*; Wei, Y.; Vandamme, T.F.; Anton, N.*
• ACS Applied Materials & Interfaces, 2019, 11(1), 403-416.
  Magnetite and iodine-containing nano-emulsion as dual modal contrast agent for X-ray/MR Imaging
  Wallyn, J.; Anton, N.*; Mertz, D.; Begin-Colin, S.; Perton, F.; Serra, C.A.; Franconi, F.; Lemaire, L.; Chiper, M.; Libouban, H.; Messaddeq, N.; Anton, H.; Vandamme, T.F.
• International Journal of Pharmaceutics, 2019, 558, 1-8.
  Production of dry-state ketoprofen-encapsulated PMMA NPs by coupling micromixer-assisted nanoprecipitation and spray drying
  Ding, S.; Serra, C.A.*; Anton, N.*; Yu, W.; Vandamme, T.F.*

2018

• ACS Omega, 2018, 3(10):14333-14340.
  Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy
  Bouchaala, R.; Richert, L.; Anton, N.; Vandamme, T.F.; Djabi, S.; Mely, Y.; Klymchenko, A.S.*
• European Journal of Pharmaceutics and Biopharmaceutics, 2018, 133, 331-338.
  Development of Doxorubicin hydrochloride loaded pH-sensitive liposomes: investigation on the impact of chemical nature of lipids and liposome composition on pH-sensitivity
  Rehman, A.; Omran, Z.; Anton, H.; Mély, M.; Akram, S.; Vandamme, T.F.; Anton, N.*
• International Journal of Pharmaceutics, 2018, 549(1-2), 299-305.
  Pickering nano-emulsion as a nanocarrier for pH-triggered drug release
  Sy, P.; Anton, N.; Idoux-Gillet, Y.; Dieng, S.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.*
• Langmuir, 2018, 34(5), 1981-1991.
  Microfluidic-assisted production of size-controlled superparamagnetic iron oxide nanoparticles-loaded poly(methyl methacrylate) nanohybrids
  Ding, S.; Attia, M.F.; Wallyn, J.; Taddei, C.; Serra, C.A.*; Anton, N.*; Kassem, M.; Schmutz, M.; Er-Rafik, M.; Messaddeq, N.; Collard, A.; Yu, W.; Giordano, M.; Vandamme, T.F.
• Acta Biomaterialia, 2018, 66, 200-212.
  A new formulation of Poly(MAOTIB) nanoparticles as an efficient contrast agent for in vivo X-ray imaging
  Wallyn, J.; Anton, N.*; Serra, C.A.; Bouquey, M.; Collot, M.; Anton, H.; Weickert, J.L.; Messaddeq, N.; Vandamme, T.
• Critical Reviews in Therapeutic Drug Carrier Systems, 2018, 35(5), 391-431.
  Inorganic nanoparticles for X-ray computed tomography imaging
  Attia, M.; Wallyn, J. ; Anton, N.*; Vandamme, T.F.*
• Colloids and Surfaces B : Biointerfaces, 2018, 175, 91-97.
  Elaboration of a thermosensitive smart biomaterial : from the synthesis to the ex vivo bioadhesion evaluation
  Conzatti, G.; Cavalie, S.; Gayet, F.; Torrisani, J.; Carrère, N.; Tourrette, A.*
• Applied Surface Science, 2018, 467-468, 940-948.
  Thermosensitive PNIPAM grafted alginate / chitosan PEC
  Conzatti, G.; Ayadi, F.; Cavalie, S.; Carrère, N.; Tourrette, A.*
• European Polymer Journal,, 2018, 105, 434-441.
  Surface functionalization of plasticized chitosan films through PNIPAM grafting via UV and plasma graft polymerization
  Conzatti, G.; Chamary, S.; De Geyter, N.; Cavalie, S.; Morent, R.; Tourrette, A.*

2017

• Scientific Reports, 2017, 7(1).
  Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions
  Anton, N.*; Parlog, A.; Bou About, G.; Attia, M.F.; Wattenhofer-Donzé, M.; Jacobs, H.; Goncalves da Cruz, I.; Robinet, E.; Sorg, T.; Vandamme T.F.
• Colloids and Surfaces B: Biointerfaces, 2017, 156, 414-421.
  Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo
  Bouchaala, R.; Anton, N.; Anton, H.; Vandamme, T.; Mély, Y.; Vermot J.; Smail, D.; Klymchenko, A.S.*
• Macromolecular Biosciences, 2017, 7(17).
  Functionalizing nano-emulsions with carboxylates: impact on the biodistribution and pharmacokinetics in mice
  Attia, M.F.; Dieng, S.M.; Collot, M.; Klymchenko, A.S.; Bouillot, C.; Serra, C.A.; Schmutz, M.; Er-Rafik, M.; Vandamme, T.F.; Anton, N.*
• Soft Matter, 2017, 13(8), 1660-1669.
  A new method for the formulation of double nano-emulsions
  Ding, S.; Anton, N.*; Akram, S.; Er-Rafik, M.; Anton, H.; Klymchenko, A.; Yu, W.; Vandamme, T.F.; Serra, C.A.*
• Petroleum Science and Technology, 2017, 35(11), 1124-1129.
  Tuning of properties of alkyl phenol formaldehyde resins in petroleum demulsifiers. 2. Interfacial dilatational properties
  Velasquez, I.; Anton, N.; Sykora, J.; Pereira, J.*
• Petroleum Science and Technology, 2017, 35(10), 1055-1062.
  Tuning of properties of alkyl phenol formaldehyde resins in petroleum demulsifiers. 1. Emulsion stability test
  Velasquez, I.; Sykora, J.; Anton, N.; Pereira, J.*
• Carbohydrate Polymers, 2017, 172, 142-151.
  Alginate/chitosan polyelectrolyte complexes : A comparative study of the influence of the drying step on physicochemical properties
  Conzatti, G.; Faucon, D.; Castel, M.; Ayadi, F.; Cavalie, S.; Tourrette, A.*
• Colloids and Surfaces B : Biointerfaces, 2017, 151, 143-155.
  PNIPAM grafted surfaces through ATRP and RAFT polymerization : chemistry and bioadhesion
  Conzatti, G.; Cavalie, S.; Combes, C.; Torrisani, J.; Carrère, N.; Tourrette, A.*
• Journal of Medical and Biological Engineering, 2017, 38, 10–21.
  Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties
  Castel, M.*; Conzatti, G.; Torrisani, J.; Rouilly, A.; Cavalie, S.; Carrère, N.; Tourrette, A.